Targanta presented the Phase III studies of its lead product, Oritavancin, at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). The findings “show significant promise in combating a critical public health issue:”
The gory details of the study and presentation can be found here, and here is a little more about Oritavancin for us laymen:
Oritavancin, Targanta’s lead product candidate, is a once-daily, semi- synthetic glycopeptide antibiotic with rapid bactericidal activity against all studied clinically relevant serious gram-positive pathogens, including multi- resistant strains. Oritavancin’s multiple targets and mechanisms of action work against the development of resistant strains, which is important when treating serious gram-positive infections. To date, 1,566 individuals have received oritavancin in clinical trials, including two large multicenter Phase III studies. Targanta expects to file a new drug application for oritavancin with the U.S. Food and Drug Administration in 2007.
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3 responses so far ↓
MRSA Notes » Medicated Gloves Being Considered to Help Curb Spread of HA-MRSA // Oct 4, 2006 at 8:07 am
[...] Also presented at the ICAAC conference was research on the use of reusable examination gloves, treated with a combination of chlorhexadine (Peridex) and a brilliant green dye - the combination is known as Gardine and is an antiseptic rather than an antibiotic. This is preliminary research from the University of Texas (gig ‘em, Ags ) showing some definite promise for future improvements in the way that hospital and food borne bacterial infections are handled. [...]
Page // Oct 26, 2006 at 1:54 pm
Christina,
I’m curious to know if the recently concluded cSSSI trials for Oritivancin addressed MRSA. I know oritivancin has in vitro data showing activity against MRSA but in vivo data is lacking. Any thoughts?
Spencer Jones // Jul 29, 2008 at 8:07 pm
Fortunately, four recent medical studies have demonstrated that an inexpensive and completely natural substance called colloidal silver decimates MRSA. You can read a very interesting report on it at http://www.ColloidalSilverCuresMRSA.com
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